Haemopoietic stem cell transplantation for genetic disorders

Autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis.

Endocrine Disorders in Childhood Cancer Survivors Treated with Haemopoietic Stem Cell Transplantation

The increasing number of haemopoietic stem cell transplantations (HSCT) taking place worldwide has offered a cure to many high risk childhood malignancies with an otherwise very poor prognosis. However, HSCT is associated with an increased risk of morbidity and premature death, and patients who have survived the acute complications continue to face lifelong health sequelae as a result of the tr...

Hematopoietic Stem Cell Transplantation for Thalassemia

Thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. For β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. Stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...

Management of cytomegalovirus infection in haemopoietic stem cell transplantation.

Department of Virology, University College London School of Life and Medical Sciences, London, Department of Virology, King’s College Hospital, London, Department of Haematology, Freeman Road Hospital, Newcastle, West of Scotland specialist virology centre, Gartnavel General Hospital, Glasgow, Birmingham HPA Laboratory, Birmingham Heartlands Hospital, Birmingham, Department of Haematology, King...

Respiratory infections following haemopoietic stem cell transplantation in children.

Disorders of the respiratory system are well recognised following the administration of chemotherapy schedules; although respiratory complications may occur following less intensive regimens, they are most frequently seen following the administration of high dose chemotherapy with or without radiotherapy which is used in preparation for haemopoietic stem cell transplantation (SCT). In this sett...